PQQ Applications Unleashed: From Pellets to Liposomes, What Works Best

1. Product Specifications:

   • Product Name: Pyrroloquinoline Quinone Disodium Salt
   • Other Name: PQQ
   • Chemical Formula: C14H4N2Na2O8
   • Appearance: Reddish brown powder
   • Specification: 99%
   • CAS NO.: 122628-50-6
   • Solubility: Soluble in water

2. PQQ Production Process:

   • The specific details of the production process are not provided, but it's mentioned that the final product is a reddish brown powder with 99% purity and is soluble in water.

1. PQQ’s Mechanism of Action:

   • Redox Cofactor: Acts as a cofactor for enzymes involved in redox reactions, facilitating electron transfers in biological processes.
   • Mitochondrial Function: Positively impacts mitochondrial function, enhancing their activity and involvement in biogenesis.
   • Antioxidant Activity: Functions as an antioxidant, neutralizing harmful free radicals, thereby protecting cells from oxidative stress.

2. Comparison with Other Antioxidant Products:

   • In a study comparing PQQ with CoQ10 and a combination of both, PQQ showed effectiveness in improving learning ability in rats, especially in the early stage of the experiment. PQQ was found to be more effective than CoQ10 alone in improving spatial cognition.

   • PQQ did not show a synergistic effect with vitamin E in improving cognitive function. However, PQQ was effective in improving cognitive deficits in rats caused by hyperoxia, outperforming CoQ10 in restoring memory function.

   • The simultaneous intake of PQQ and CoQ10 did not improve the learning ability of rats but improved memory function impairment, suggesting a synergistic inhibition of oxidative stress.

3. Application Examples of PQQ:

   • Three dosage forms are provided: PQQ, liposomal PQQ, and PQQ pellets.
   • Liposomal PQQ and PQQ pellets have higher absorption and utilization rates than PQQ powder. Liposomal PQQ has a structure similar to human cell membranes, aiding direct absorption.
   • PQQ pellets protect PQQ from stomach acid, allowing it to be released in the intestine, improving absorption.   

4. PQQ’s Applications and Common Combinations in the Market:

   • Available in various forms and combinations, including PQQ 10mg, PQQ 20mg, PQQ 20mg + CoQ10 200mg, PQQ + Trans-resveratrol + NAD + CoQ10, and PQQ + CoQ10 + Glutathione.

This information provides insights into the properties, production, mechanisms of action, and applications of PQQ, including its comparison with other antioxidants and common combinations in the market.